Download PDF by T.K. Ghose ,A. Fiechter, N.Blakebrough: Advances in Biochemical Engineering, Volume 008: Mass

By T.K. Ghose ,A. Fiechter, N.Blakebrough

ISBN-10: 3540085572

ISBN-13: 9783540085577

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Additional info for Advances in Biochemical Engineering, Volume 008: Mass Transfer in Biotechnology

Example text

36 M. U,OS I ~ f 103 . l NEWTONIAN I t l I 104 I 105 FLUIDS ~E Z iO 2. iO m I i01 i0 ° I i0 2 I 103' i0 6 NRe Fig. 25. Mixing time correlations for non-aerated Newtonian and non-Newtonian fluids, turbine impeller [ 81 ] Nevertheless, available correlations do serve as valuable guides. One of the more recent correlations for top-entering impellers is that given by Nagata [88]: 1 _ 1 Nm OmN i. 21 dT\j~/(1 _ e l ~ , / ~ ) ( N ~ e ~ 10'), (41) where Nm NQ = mixing number = OmN = discharge number = Q/N d~ Np = power n u m b e r = NRe = Rey n o l d s n u m b e r - N d ~ 0m N di T Q p p v = = = = = = = = Pgc (42) (43) (44) o N 3d s v and mixing time impeller rotational speed impeller diameter tank diameter volumetric circulation rate in tank power input fluid density kinematic viscosity.

3. Variation in rheological conditions of batch. 4. Some evidence for depolymerase activity near end of batch. Yes 1. 5% (Fig. 22). 2. 6% max) had little or no effect on viscosity measur~ ments. [621 Xanthomonas campestris 1571 X. 0 Brookfield (guard removed) Yes t. Whole and filtered broth obeyed power law (Fig. 19). 2. Cells had minor effect on K, virtually no effect on m. 5 or 10 Brookfield (guard removed) No 1. Viscosity increases monotonically with reaction time. 2. Nature of rheological behavior not discussed.

1 the observed rate of reaction is governed by the mass transfer rate: (54) rA - k L a s C A However, if mass transfer is much more rapid than the reaction rate ~ kl ~ 1 , the observed rate is dependent on the intrinsic kinetics of the reaction: rA -' kl CA. (55) It is generally preferable to operate under conditions favoring reaction rate control. This requires maximization of the mass transfer coefficient, kL, and hence consideration of rheological properties. The effects o f a s on the mass transfer rate must also be considered but these are difficult to analyze because morphological properties influence theological properties and also introduce questions requiring consideration of "pore" diffusion.

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Advances in Biochemical Engineering, Volume 008: Mass Transfer in Biotechnology by T.K. Ghose ,A. Fiechter, N.Blakebrough


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