New PDF release: Anatomy of a Scientific Discovery: The Race to Find the

By Jeff Goldberg

ISBN-10: 1626361932

ISBN-13: 9781626361935

In past due 1973, scientists John Hughes and Hans Kosterlitz spent the vast majority of their time in an underfunded, imprecise, and cramped laboratory in Aberdeen, Sweden. whereas engaged on the brains of pigs, the duo stumbled on a nonaddictive narcotic chemical that they was hoping to later locate in human brains. in the event that they may perhaps isolate this chemical in people, maybe they can have the ability to aid the area start to heal itself. Hughes and Kosterlitz’s study might unavoidably cause them to observe endorphins, the body’s personal usual morphine and the chemical that makes it attainable to consider either discomfort and pleasure.

Announcing their findings to the medical global thrust Hughes and Kosterlitz within the highlight and made them celebrities. quickly, scientists world wide have been swiftly reading the human mind and its endorphins. In many years’ time, they might use the team’s preliminary study to hyperlink endorphins to drug dependancy, runner’s excessive, urge for food keep watch over, sexual reaction, and psychological health problems resembling melancholy and schizophrenia.

In Anatomy of a systematic Discovery, Jeff Goldberg describes Hughes and Kosterlitz’s lives ahead of, in the course of, and after their historical and medical step forward. He additionally takes a glance on the greater photograph, revealing the brutal festival among drug businesses to discover how to take advantage of this huge discovery.

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Extra resources for Anatomy of a Scientific Discovery: The Race to Find the Body's Own Morphine

Example text

It was a memorable night. ” In January 1972, Liebeskind went to Paris on a one-year sabbatical, leaving Akil working to complete a more extensive study with naloxone, an even purer opiate antagonist than nalorphine. He sent her final results to the journal of the French Academy of Science, Contes Rendus, where an article on SPA coauthored by Akil and Liebeskind had appeared just one month before Akil gave her talk in San Francisco. In San Francisco, Hans Kosterlitz and Avram Goldstein, in their individual ways, contemplated the meaning of new information that naloxone would reverse the amazingly morphine-like effects of SPA.

She had spent the next thirty-five years putting up with his obsessions. Hanna was a small, wispish woman whose attitudes and opinions were for the most part old-fashioned. The subject of serious scientists, however, provoked an outspoken feminist response. “Never marry a dedicated scientist,” she advised girls who came to their parties. “A dedicated scientist is married to his work—if I’m ever born again, I’ll never marry a scientist. ” In the early 1940s Kosterlitz’s research had shifted to the influence of dietary protein on the composition of the liver, in the hope that this work would help provide a solution to the serious food shortages during the war, but it had finally proven less than successful.

Medical students at the university had nicknamed him “Mr. ” What it meant was so startling that even Kosterlitz still distrusted his conclusion, which remained known only to his closest colleagues. In the early 1960s—ten years before Hughes’s trips to the slaughterhouse began—Kosterlitz had predicted that morphine worked by imitating a chemical already in the body, an endogenous opiate. He had observed that opiates seemed to produce their twitch-quelling effects in a unique way. Their depressant action, he suggested, was “presynaptic” and “neuromodulating”—the drugs acted before the nerve impulse reached its terminus at the end of the cell, slowing it down and reducing the release of acetylcholine, the transmitter he found to be primarily responsible for passing the twitch response along the nerve fiber.

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Anatomy of a Scientific Discovery: The Race to Find the Body's Own Morphine by Jeff Goldberg


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