Download PDF by Ulf Landmesser, Helmut Drexler (auth.), Martial G. Bourassa,: Antioxidants and Cardiovascular Disease

By Ulf Landmesser, Helmut Drexler (auth.), Martial G. Bourassa, Jean-Claude Tardif (eds.)

ISBN-10: 0387295526

ISBN-13: 9780387295527

ISBN-10: 0387295534

ISBN-13: 9780387295534

Antioxidants and heart problems, moment version addresses a fancy yet very well timed and interesting challenge in cardiovascular medication. it's written via well-known specialists within the fields of atherosclerosis and antioxidants. it may be of curiosity not just to academicians but in addition to practising physicians. the 1st 5 chapters assessment the final suggestions of oxidative tension and their dating to lipid metabolism, endothelial disorder, genetics and transcriptional components. the following seven chapters describe lately outlined markers of oxidative tension, pharmacological compounds with antioxidant task, traditional antioxidants present in micronutrients and in nutrient-rich diets, and experiences the hot facts for his or her efficacy or loss of efficacy in sufferers with heart problems or cardiovascular hazard components. The final seven chapters talk about the capability healing advantages of antioxidants in a few cardiovascular stipulations which come with atherosclerosis, restenosis after percutaneous coronary intervention, significant cardiovascular danger elements resembling high blood pressure, diabetes mellitus and dyslipidemia, and left ventricular disorder and congestive center failure.

Martial G. Bourassa, M.D. and Jean-Claude Tardif, M.D. are affiliated with the Montreal middle Institute, examine heart and division of drugs, college of medication, college of Montreal, Montreal, Quebec, Canada.

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78. 79. 80. 81. 15 Grote K, Flach I, Luchtefeld M, et al Mechanical stretch enhances mRNA expression and proenzyme release of matrix metalloproteinase-2 (MMP-2) via NAD(P)H oxidasederived reactive oxygen species. Circ Res 2003;92:e80-6. Ceriello A, Motz E. Is Oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arterioscler Thromb Vase Biol 2004;24:816-23. Blendea MC, Jacobs D, Stump CS, et al. Abrogation of oxidative stress improves insulin sensitivity in the ren2 rat model of tissue angiotensin II overexpression.

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Br J Pharmacol 1997; 120:1199-206. Bocan TM, Rosebury WS, Mueller SB et al. A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemiainduced atherosclerosis in the rabbit. Atherosclerosis 1998;136:203-16. George J, Afek A, Shaish A et al. 12/15-Lipoxygenase gene disruption attenuates atherogenesis in LDL receptor-deficient mice. Circuladon 2001;104:1646-50. Harats D, Shaish A, George J et al. Overexpression of 15-lipoxygenase in vascular endothelium accelerates early atherosclerosis in LDL receptor-deficient mice.

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Antioxidants and Cardiovascular Disease by Ulf Landmesser, Helmut Drexler (auth.), Martial G. Bourassa, Jean-Claude Tardif (eds.)


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