Download e-book for iPad: Antiplatelet Therapy In Ischemic Heart Disease (American by Stephen D. Wiviott

By Stephen D. Wiviott

ISBN-10: 1405176261

ISBN-13: 9781405176262

ISBN-10: 1444303341

ISBN-13: 9781444303346

* attracts from services of leaders in antiplatelet remedy* Easy-to-use structure permits quick looking* Edited by means of a member of the celebrated TIMI examine crew with long-standing event within the box

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Additional info for Antiplatelet Therapy In Ischemic Heart Disease (American Heart Association Clinical Series)

Sample text

4 The Impact® cone and plate(let) analyzer. Chapter 2 Assessment of platelet function 23 cone in a standardized cup [19]. After automated staining, platelet adhesion to the cup is evaluated by image analysis software. Advantages of the Impact® include: point-of-care (although, unlike the VerifyNow® device, pipetting of the blood sample is required), simplicity, rapidity, low sample volume, physiologically relevant high shear, and a whole blood system. The assay has been used to monitor GP IIb/IIIa antagonist therapy.

Turbidometric platelet aggregation has been the platelet function test most often used in clinical trials. Several studies have reported that platelet aggregometry can predict major adverse cardiac events (MACE), although the number of MACE in all these studies was low [10–12]. There are major disadvantages to platelet aggregometry as a clinical test of platelet function, including high sample volume, requirement for sample preparation, length of assay time, requirement of a skilled technician and expense [9].

4 Hawkey CJ. COX-2 chronology. Gut 2005; 54: 1509–1514. html# 6 Vane JR, Botting RM. Mechanism of action of nonsteroidal anti-inflammatory drugs. Am J Med 1998; 104: 2S–8S. 7 Awtry EH, Loscalzo J. Cardiovascular drugs. Circulation 2000; 101: 1206. 8 Weiss HJ. The discovery of the antiplatelet effect of aspirin: a personal reminiscence. J Thromb Haemost 2003; 1: 1869–1875. 9 Vane J. Towards a better aspirin. Nature 1994; 367: 215–216. 10 Picot D, Loll PJ, Garavito RM. The Xray crystal structure of the membrane protein prostaglandin H2 synthase 1.

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Antiplatelet Therapy In Ischemic Heart Disease (American Heart Association Clinical Series) by Stephen D. Wiviott


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