By Kewal K. Jain
For physicians, surgeons, and scientists engaged on cardiovascular issues, Applications of Biotechnology in Cardiovascular Therapeutics serves as a useful reference via accumulating the fundamental writings of Dr. Kewal okay. Jain at the subject matters of biotechnology as they relate to heart problems. This thorough quantity comprises such matters as biotechnology and healing supply to the cardiovascular process, cell-selective precise drug supply, mobilephone and gene treatments, together with antisense and RNA interference, state of the art gene remedy techniques, in addition to customized cardiology as a fashion of integrating new applied sciences into the choice of the absolute best remedy for somebody sufferer. chosen references from fresh literature are accumulated for every bankruptcy, and the textual content is supplemented via a number of beneficial tables and figures.
Comprehensive and up to date, Applications of Biotechnology in Cardiovascular Therapeutics can be significantly precious for these operating in lifestyles sciences and the pharmaceutical sciences, and the inclusion of a few fundamentals of cardiovascular illnesses will drastically gain nonmedical readers as well.
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Extra info for Applications of Biotechnology in Cardiovascular Therapeutics
Mass spectrometry analysis identifies a set of proteins in the heart altered with acute or chronic rejection. ELISA (enzymelinked immunosorbent assays) have identified proteins in serum samples of patients that are potential noninvasive biomarkers of acute and/or chronic rejection. Validation of these diagnostic markers requires analysis of larger sets of patient and serum samples. Early detection of rejection is important as it provides an opportunity for treatment with immunosuppressant therapy.
The skin temperature is low and there may be pallor or reddish blue discoloration. There may be ulceration or gangrene of the affected extremity. Reduction of blood flow to a limb is due to stenosis of the arteries. Stenosis that decreases the cross-sectional area of an artery by less than 75% usually does not affect the resting blood flow to the limb; lesser degrees of stenosis may induce muscle ischemia during exercise. The presence or absence of ischemia in the presence of obstruction is also determined by the degree of collateral circulation.
This provides the foundation for rational and innovative approaches to cardiovascular therapeutics. Molecular Cardiology 9 Cardiogenomics The term cardiogenomics refers to the role of genes in cardiovascular system. Microarrays are being applied to study gene expression. The patterns in the variation of expression of many genes correlate well with the models currently used to explain the pathogenesis of cardiovascular diseases. More complete genomic maps allow easier identification of genes that cause monogenic inherited diseases.
Applications of Biotechnology in Cardiovascular Therapeutics by Kewal K. Jain