By William H. Frishman M.D., Angela Cheng-Lai Pharm.D. (auth.), William H. Frishman M.D., Angela Cheng-Lai Pharm.D., Julie Chen Pharm.D., BCPS (eds.)
The 3rd variation of present Cardiovascular medications is designed to supply an up to date useful compendium of present wisdom relating to cardiovascular drug treatment in a concise, simply readable structure. The ebook is prepared into chapters by means of drug classification, and information the pharmacologic features of particular therapy entities. The medical efficacy and obstacles of a few of the drug remedies are mentioned utilizing supportive reference fabric from the main authoritative resources and released medical trials.
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Additional info for Current Cardiovascular Drugs
Pancreatitis (S I%). %),upper respiratory lnfeaion (2%) Dermatologic: rash (S I%), prurfws (S I%), photosensitivity (S I%), flushing (S I%) Renal: elevations of BUN or serum creatinine Othe~: angioedema (S I%). syncope (S I%). ation of action: 2>4 h Ons t of action: I h P k efli ct: 2-6 h Bloavallabllity: 36% Effect of food : decreased rate of absorption. unknown clinical slgnlfiance Metabolism: converted to foslnoprllat In the liver; fosinoprl· lat Is also conjugated to the beta-glucuronide. Ell min tlon: cleared equally by renal and hepatic routes Half-life: 12 h (foslnoprilat) Protein binding: 97%-98" (foslnoprilat) MONITORING BP-Observe arefully for first-dose hypotension, especially In patients with heart failure.
Dininess (4%). fatigue (2%-3%). %), diarrhea (3%). hepadtis (< I%). upper respiratory Infection(> 1%) Dermato logic rash (I %-2%), pruritus (< I%). photosensitivity (< I%), flushing ( I%-2%) Renal: elevations of BUN or serum creatinine Others:angloedema (< l %). syncope (< I%). myalgia ( I%-2%). elevations of liver function wts. blllty: 13% as moe1dprllat Effect of food: C'""" and AUC are markedly reduced when moexiprllls taken with food. Therefore, this agent should be taken In a fasting state Metabolism: both moexlpril and moexlpllat are converted to dlketoplperulne derivatives and unidentified metabolites Elimination: 13% In urine (7% as moexlprllat.
Jial111farctmn. N l! t~gl J Mt•tl 1995, ~ : 167 - 1676. :okmetic pmpcrtic and thcmpcut1c u c 111 hypcrtcn mn and cong •sti e hean failure. Drug\ 1988. 15:64 669. Lutini R. Magginni AP. Hathcr M, eta/. : A inhibitor u e in pati nt with myocardial infarction: ummary of e idcncc from clinicultnal irmlatirm 1995. 92:31 2- 137. Leonetti u. pidi : hoosin • the right inhibito • a guide to election. Drug~ 1995, 49:51 535. wi . Hunsicker LG. Bain RP. yme inhibition on diubcti nephropathy. N At~RI J M c/199 •.
Current Cardiovascular Drugs by William H. Frishman M.D., Angela Cheng-Lai Pharm.D. (auth.), William H. Frishman M.D., Angela Cheng-Lai Pharm.D., Julie Chen Pharm.D., BCPS (eds.)