By Martine J. Smit, Sergio A. Lira, Rob Leurs, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
Chemokines are hormone-like signaling molecules secreted by way of cells to sign an infection and consultant the immune reaction. Following a decade of uncomplicated chemokine study, the pharmaceutical has now began to use this important signaling pathway for the advance of leading edge medications opposed to AIDS, melanoma, neural and autoimmune illnesses. this is the 1st reference targeting those novel drug improvement opportunities.
starting with a basic advent on chemokine functionality and chemokine receptor biology, the second one half covers the identified implications of those signaling molecules in human ailments, equivalent to melanoma, neural problems, and viral an infection, together with AIDS. The 3rd half systematically surveys present drug improvement efforts at focusing on person chemokine receptors, in addition to different chemokine interplay companions, together with up to date studies from the pharmaceutical industry.